Fluorescence Studies on Cancer* I. Porphyrin Metabolism, Harderian Gland Fluorescence, and Susceptibility to Carcinogenic Agents
نویسنده
چکیده
It is well known that different species (8, 14, 35, 36, 44) and different organs and tissues (45) vary greatly in their susceptibility to carcinogenic agents. The only animals that have been extremely susceptible to the induction of tumors by means of physical and pure chemical agents are mice and rats. It has been found difficult and frequently impossible to produce tumors by the same methods even in other rodents (36). Shear (36) lists several investigators who found rabbits and guinea pigs refractory to the action of carcinogens that are potent in mice. By the administration of relatively tremendous quantities of methylcholanthrene, tumors have been induced in cottontail rabbits (39). Shimkin and Mider (37) induced tumors in a relatively high percentage of guinea pigs by subcutaneous injection of large doses of methylcholanthrene. From a tabulation of their own results and those of others (23, 33, 42) they state that, " . . . the relative carcinogenic potency of 20-methylcholanthrene, 3,4-benzpyrene, and 1,2,5,6-dibenzanthracene in guinea pigs is the same as in mice and rats (Fieser) but that guinea pigs are more resistant to the induction of subcutaneous neoplasms with these agents." Monkeys continue to resist the most drastic treatments with chemical carcinogens (1) and estrogenic compounds (1, 13); in the human subject, 3,4-benzpyrene has been used to treat 22 spontaneous neoplasms and 7 cures were described (2). It has been postulated that certain unique features in the porphyrin metabolism of rats and mice are responsible for the extreme sensitivity of these animals to carcinogenic agents. The early observations (18) relating porphyrin metabolism and red fluorescence of the harderian gland to cancer susceptibility were
منابع مشابه
The possible association between porphyrins and cancer in mice.
Since a method was available (13) that could easily be adapted to a quantitative determination of porphyrins in the harderian glands of mice, it SeClned advisable, in view of recent publications by others, to ascertain if there might be any relationship between porphyrin metabolism and the possible causes of thc various types of cancer, especially mammary cancer, in mice. Strong and Figge (18) ...
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تاریخ انتشار 2007